Regulatory Mechanisms of lncRNAs and Their Target Gene - PubMed PLoS One. GNC Lean Shake 25 Review: Don't Buy Before You Read This! Exogenous expression of miR-135a-5p could enhance apoptosis resistance to ADR in gastric cancer cells via silencing activating protein 2 alpha (AP-2) and, thus, upregulating Bcl-2 expression [55]. For example, it has been found that miR-520h down-regulated expression of HDAC1, which contributing to ADR resistance of gastric cancer [63]. 2018;9:584. Int J Cancer. GNC Total Lean Lean Shake Green Powder - 27 oz | GNC There are a total of three generations of platinum drugs including cisplatin as the first-generation platinum drug, carboplatin as the second-generation platinum drugs, as well as oxaliplatin and loplatin as the third-generation platinum drugs. / Tumour Biol. 2019;70:4254 e3. 2019;52(4):e12648. LncRNAs UCA1 and HULC have also been found to promote 5-FU resistance [168, 169]. GNC Total Lean | Lean Shake 25, To Go Bottles | Low-Carb Protein Shake Part of Additionally, exogenous expression of miR-197 and miR-BART15-3p could also strongly promote 5-FU chemosensitivity through down-regulating expression of mitogen-activated protein kinase 1 (MAPK1) and Tax1-binding protein 1 (TAX1BP1), respectively [134, 135]. DNA Cell Biol. Yu Y, Yu X, Liu H, Song Q, Yang Y. miR494 inhibits cancerinitiating cell phenotypes and reverses resistance to lapatinib by downregulating FGFR2 in HER2positive gastric cancer. WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov., Consult your physician prior to using this product if you are pregnant, nursing, taking medication or have a medical condition. GNC Total Lean | Lean Shake 25 Protein Powder - Walmart.com Eur Rev Med Pharmacol Sci. Downregulation of microRNA-4295 enhances cisplatin-induced gastric cancer cell apoptosis through the EGFR/PI3K/Akt signaling pathway by targeting LRIG1. The required labels on electrical wires such as computer cables, power cords, and holiday lights sold in California are slightly different from the labels on other products, and typically say something like this: WARNING:Handling the cord on this product will expose you to lead, a chemical known to the State of California to cause [cancer, and] birth defects or other reproductive harm. LncRNA DANCR accelerates the development of multidrug resistance of gastric cancer. Similarly, an evidently high expression lncRNA DANCR has been identified in SGC7901/DDP and BGC823/DDP DDP-resistant gastric cancer cells. I like 2 full scoops of the Rich Chocolate. MicroRNA-362-5p enhances the cisplatin sensitivity of gastric cancer cells by targeting suppressor of zeste 12 protein. If you see a warning label of this type, you may want to check ConsumerLab.com's website to see if there is information about the product. Epstein-Barr virus miR-BART20-5p regulates cell proliferation and apoptosis by targeting BAD. 2018;97(35):e12007. 2016;71(11):6403. However, the detailed mechanisms of MDR remain inconclusive. Upregulation of microRNA-34a enhances the DDP sensitivity of gastric cancer cells by modulating proliferation and apoptosis via targeting MET. Cancer Lett. Sun KK, Shen XJ, Yang D, Gan MQ, Liu G, Zhang YF, et al. Tumor suppressor miR-195-5p, miR-204, miR-623, miR-939 and miR-124 have been shown to be involved in overcoming 5-FU resistance of gastric cancer via silencing Zing finger 139 (ZNF139), TGFBR2, cyclin D1 (CCND1), solute carrier family 34 member 2 (SLC34A2) and EZH2, respectively [136,137,138,139,140]. Potentiation of the anticancer effect of doxorubicinin drug-resistant gastric cancer cells by tanshinone IIA. Shang Y, Feng B, Zhou L, Ren G, Zhang Z, Fan X, et al. 2018;27(1):1927. Article Ask the manufacturer how a person might be exposed to the chemical(s) of concern from this product. Zeng L, Liao Q, Zou Z, Wen Y, Wang J, Liu C, et al. The label doesnt have to say anything about how much of the chemical(s) the product contains, or how you might be exposed to it. It has, for example, been found that tumor suppressor miR-27b, miR-508-5p, miR-129-5p and miR-107 could inhibit expression of certain family member of ABC transporters and, thus, enhance sensitivity of gastric cancer cells to 5-FU [64, 65, 67, 69]. Chun-Zhi Z, Lei H, An-Ling Z, Yan-Chao F, Xiao Y, Guang-Xiu W, et al. GNC Total Lean Advanced Advanced Protein Bar Breakfast (200 Calories) 2 scoops Lean Shake Burn 1/3 C blueberries Lunch (450 Calories) Tuna & Feta Salad 2 C salad greens topped with 6 oz light canned tuna (in water), 1 oz feta cheese, 8 cherry Liu X, Ru J, Zhang J, Zhu LH, Liu M, Li X, et al. Biosci Rep. 2019;39(12):BSR20193045. An increasing number of ncRNAs have been identified to be involved in drug resistance of gastric cancer. 2018;42(2):9981007. We can connect you with trained cancer information specialists who will answer questions about a cancer diagnosis and provide guidance and a compassionate ear. 2015;348(6230):1248. GNC Total Lean Swiss Chocolate. 2017;40(4):30339. GNC Total Lean Lean Shake 25 - Banana Cream - 12 Bottles Korourian A, Madjd Z, Roudi R, Shariftabrizi A, Soleimani M. Induction of miR-31 causes increased sensitivity to 5-FU and decreased migration and cell invasion in gastric adenocarcinoma. DUSP4 promotes doxorubicin resistance in gastric cancer through epithelial-mesenchymal transition. 2. Some common exposure routes include inhalation, contact with food, transfer to food or drink from unwashed hands, or a baby or child putting the product in their mouth. All these elucidate the potential of circRNAs as markers for diagnosis and therapy of cancers [193,194,195]. Cell Oncol (Dordr). Li B, Wang W, Li Z, Chen Z, Zhi X, Xu J, et al. World J Gastroenterol. Theranostics. 2020;27(1):1073274820904694. Some companies that sell products all over the US only label those sent to California, even though all their products contain the same compounds. Int J Mol Med. 2019;42(2):13141. A Prop 65 warning on your food or supplement label doesn't necessarily mean the product is unsafe, or that you shouldn't take it. Guo Z, Zhang J, Fan L, Liu J, Yu H, Li X, et al. Amazon.com: GNC Total Lean | Lean Shake 25 Protein Powder | High In addition, lncRNAs HULC and NEAT1 are also involved in enhancing ADR resistance of gastric cancer cells [169, 187]. Wash hands after handling. Terms and Conditions, Recently, emerging evidences indicate that miRNAs are involved in MDR controlling by regulating autophagy through targeting autophagy related genes. J Oncol. Notch 1 promotes cisplatin-resistant gastric cancer formation by upregulating lncRNA AK022798 expression. Wang L, Chunyan Q, Zhou Y, He Q, Ma Y, Ga Y, et al. miR-101 alleviates chemoresistance of gastric cancer cells by targeting ANXA2. 2019;459:12234. Springer Nature. Fact sheets for some of the chemicals on the list are available at: https://www.p65warnings.ca.gov/fact-sheets. HOTAIR enhanced paclitaxel and doxorubicin resistance in gastric cancer cells partly through inhibiting miR-217 expression. Lean Shake 25 is a delicious meal replacement packed with protein, fiber and other essential nutrients to help you on your journey. Teng R, Hu Y, Zhou J, Seifer B, Chen Y, Shen J, et al. If you make a statement of fact, such as whether a type of treatment does or does not work, state your basis -- such as personal experience or a published study. Nie H, Mu J, Wang J, Li Y. miR1955p regulates multidrug resistance of gastric cancer cells via targeting ZNF139. GNC Total Lean Lean Shake 25 - Cookies and Cream: Packed With Protein, Fiber & Other Essential Nutrients When hunger strikes, you can still satisfy it without comprising your weight loss goals. miR-23a targets interferon regulatory factor 1 and modulates cellular proliferation and paclitaxel-induced apoptosis in gastric adenocarcinoma cells. PubMed GNC Lean Shake Review (2023) - Should You Buy It? Mol Cell Pharmacol. The Epitranscriptome of Noncoding RNAs in Cancer. Shao L, Chen Z, Soutto M, Zhu S, Lu H, Romero-Gallo J, et al. Noncoding RNAs in gastric cancer: implications for drug resistance, https://doi.org/10.1186/s12943-020-01185-7, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/, Non-coding RNAs and RNA modifiers in cancer progression and cancer cells resistance to therapies. 2019;468:88. Sun J, Bao S, Xu D, Zhang Y, Su J, Liu J, et al. Purchase this product at GNC or www.gnc.com. Int J Oncol. Zou J, Xu Y. MicroRNA-140 Inhibits Cell Proliferation in Gastric Cancer Cell Line HGC-27 by Suppressing SOX4. Wen L, Cheng F, Zhou Y, Yin C. MiR-26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2. I requested an amino acid profile to see what's in Lean 25 protein. Xu YD, Shang J, Li M, Zhang YY. 2013;587(18):306975. 3. 2019;54(1):32638. Healthy addition to your daily meal plan. PubMed Restoration of miR-34 in gastric cancer cells suppresses growth and increased apoptosis through down-regulating expression of Bcl-2, Notch, and high-mobility group AT-hook 2 (HMGA2) [74]. 2008;8:266. volume19, Articlenumber:62 (2020) 2017;8(1):57482. Long Non-Coding RNA (LncRNA) Urothelial Carcinoma Associated 1 (UCA1) Increases Multi-Drug Resistance of Gastric Cancer via Downregulating miR-27b. Gastric cancer is the fourth most common malignancy and the third leading cause of cancer-related deaths worldwide. ConsumerLab.com uses JavaScript to provide the best possible experience for our content, but your browser has it disabled. Accessed at https://www.p65warnings.ca.gov/new-proposition-65-warnings on May 6, 2019. It has been found that EB virus miRNA miR-BART20-5p significantly increased 5-FU resistance of AGS1 gastric cancer cells by inhibiting BAD expression [56]. Zhao Q, Li Y, Tan BB, Fan LQ, Yang PG, Tian Y. HIF-1alpha Induces Multidrug Resistance in Gastric Cancer Cells by Inducing MiR-27a. Fuels metabolism & supports lean muscle. GNC Total Lean. Several miRNAs are involved in resistance resistance to these drugs (Table 7). In an effort to protect themselves from potential lawsuits in California for not displaying a required warning, some companies may affix the Prop 65 warning labels to products -- as well as to website pages about products -- regardless of whether or not the specific products exceed Prop 65 limits. 2018;119(9):722634. Are there FDA approved & registered laboratories for dietary supplements? 2017;21(9):192943. PubMed Only the labels are new. Zhang F, Li Y, Xu W, He L, Tan Y, Xu H. Long non-coding RNA ZFAS1 regulates the malignant progression of gastric cancer via the microRNA-200b-3p/Wnt1 axis. It is intended to help Californians make informed decisions about protecting themselves from chemicals that could cause cancer, birth defects, or other reproductive harm. Wang M, Zhang R, Zhang S, Xu R, Yang Q. MicroRNA-574-3p regulates epithelial mesenchymal transition and cisplatin resistance via targeting ZEB1 in human gastric carcinoma cells. For most people, this means less than 50 net carbs per day. Cao W, Wei W, Zhan Z, Xie Y, Xiao Q. MiR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1. One of the first things we noticed when reviewing this shake is that, surprisingly, it only has about 9 grams of protein per serving. Eto K, Iwatsuki M, Watanabe M, Ida S, Ishimoto T, Iwagami S, et al. 2018;41(4):195866. Oncol Rep. 2016;36(1):26370. Onco-lncRNAs zinc finger antisense 1 (ZFAS1) and BCAR4 could promote DDP resistance of gastric cancer via activating the Wnt signaling pathway [173, 174]. Han X, Zhang JJ, Han ZQ, Zhang HB, Wang ZA. Life Sci. 2019;25(35):53009. 2019;33(1):26474. Yang M, Shan X, Zhou X, Qiu T, Zhu W, Ding Y, et al. Cell Biochem Biophys. 2017;90:70512. A Competing Endogenous RNA Network Reveals Novel Potential lncRNA, miRNA, and mRNA Biomarkers in the Prognosis of Human Colon Adenocarcinoma. 2018;12:40519. A variety of miRNAs, such as miR-1271, miR-143 and miR-503, have been observed to be involved in the IGF1R/IRS1 pathway-mediated DDP resistance of gastric cancer [101,102,103]. In press. Some types of products are required to have specific labels as a result of court orders after lawsuits. As an anti-microtubule drug, VCR could inhibit tubulin polymerization and disable spindles formation, which leading to mitosis arrest of malignant cells. Shukla GC, Singh J, Barik S. MicroRNAs: Processing, Maturation, Target Recognition and Regulatory Functions. Combine the use of high=protein Lean 25 with the diet and exercise plan included with this product. ConsumerLab.com name and flask logo are both registered trademarks of ConsumerLab.com, LLC. JAMA Oncol. Supports healthy, normal cholesterol levels. Cancer Lett. Knockdown of hsa_circ_0081143 inhibited tumorigenesis and remarkably sensitized gastric cancer cells to DDP in vivo. Join now to add comments and get all member benefits, including over 1,400 reviews. The funding bodies did not play any role in writing the manuscript. Zhang XL, Shi HJ, Wang JP, Tang HS, Wu YB, Fang ZY, et al. PubMed The Major Takeaways. For example, the required labels on electrical wires such as computer cables, power cords, and holiday lights sold in California are slightly different. This feature is restricted to active members. Advanced gastric cancer patients can notably benefit from chemotherapy including adriamycin, platinum drugs, 5-fluorouracil, vincristine, and paclitaxel as well as targeted therapy drugs. Learn about bioengineered ingredients in foods and dietary supplements, where to find a list of bioengineered foods and what to look for on labels, as well as where you can find information about bioengineered ingredients in dietary supplements in ConsumerLab's product reviews. Xie L, Zhang Z, Tan Z, He R, Zeng X, Xie Y, et al. For instance, miR-34c-5p, which was found to be significantly down-regulated in PTX-resistant gastric cancer tissues, could sensitize SGC7901/VCR resistant cells to PTX via targeting and suppressing microtubule-associated protein tau (MAPT) [147]. Answer (1 of 10): Shakes are not known to cause cancer. That is a little low for a protein shake and ideally, it should have between 12 and 17 . PubMed Cancer Gene Ther. Bang YJ, Van Cutsem E, Fuchs CS, Ohtsu A, Tabernero J, Ilson DH, et al. A number of lncRNAs have been identified to be abnormally expressed in gastric cancer and involved in chemoresistance via regulation of different target genes. 20 years ago, a drug that killed 10%, but cured HIV would have been approved because HIV was a guaranteed death sentence. Text Alternative for Dont Fry: Preventing Skin Cancer, American Cancer Society Recommendations for Human Papilloma Virus (HPV) Vaccine Use, What Parents Should Know About the HPV Vaccines, Understanding Genetic Testing for Cancer Risk. Several oncogenic miRNAs promote 5-FU resistance of gastric cancer cells, such as miR-BART20-5p, miR-193a-3p, miR-147 and miR-17. Jian B, Li Z, Xiao D, He G, Bai L, Yang Q. Downregulation of microRNA-193-3p inhibits tumor proliferation migration and chemoresistance in human gastric cancer by regulating PTEN gene. 2017;16(1):18. PubMed The hidden dangers of protein powders - Harvard Health miR-23b-3p regulates the chemoresistance of gastric cancer cells by targeting ATG12 and HMGB2. Shop GNC Total Lean Lean Shake - Swiss Chocolate at GNC. With just two delicious shakes per day and a few simple lifestyle changes . My supplement label warns that it contains a chemical known to the State of California to cause cancer, birth defects, or other reproductive harm, but with no additional information. Additionally, we propose the potential clinical implications of ncRNAs as novel therapeutic targets and prognostic biomarkers for gastric cancer. Several oncogenic miRNAs can promote PTX resistance, such as miR-21, miR-23a and miR-155-5p. PubMed In addition, circRNA circ-PVT1 could facilitate paclitaxel (PTX) resistance of gastric cancer cells via up-regulating ZEB1 mediated by miR-124-3p [23]. Zhang J, Zhao B, Chen X, Wang Z, Xu H, Huang B. Save money by finding high-quality products at lower cost. Clinically proven results^. 2015;8(6):6397406. Helps you feel fuller, longer. Among these drugs, trastuzumab and ramucirumab have been found to improve prognosis of advanced gastric cancer patients [34, 150,151,152,153]. Become a myGNC Rewards Member Save $30 on $150 Code: JULY30 Save 10% with In-Store Pick Up Summer Savings! Lu C, Shan Z, Li C, Yang L. MiR-129 regulates cisplatin-resistance in human gastric cancer cells by targeting P-gp. miR-3174 Contributes to Apoptosis and Autophagic Cell Death Defects in Gastric Cancer Cells by Targeting ARHGAP10. Reduction of circular RNA Foxo3 promotes prostate cancer progression and chemoresistance to docetaxel. $24.99 $ 24. 2015;37(4):157280. So chemotherapy is essentially a poison and you toe the line of giving enough to kill the cancer, but not enough to kill the patient. Products that are sold outside of California are not required to have the warning label even if they contain substances that might cause cancer. GNC Lean Shake, Swiss Chocolate nutrition grade D plus 170 Calories Per Serving 0 comments No rating 0 followers Explanations Keto: net carbs 3g If you are following a ketogenic diet (keto), you need to restrict your daily carbohydrate intake so that your body enters ketosis. Du X, Liu B, Luan X, Cui Q, Li L. miR-30 decreases multidrug resistance in human gastric cancer cells by modulating cell autophagy. MiR-23a, which is dramatically up-regulated in human gastric cancer tissues, has been shown to weaken PTX-induced apoptosis and accelerate proliferation of BGC823 and MGC803 gastric cancer cells via suppressing expression of interferon regulator factor 1 (IRF1) [144]. Additionally, oncogenic lncRNAs MALAT1 and PVT-1 could contribute to 5-FU resistance of gastric cancer by modulating expression of the miR-23b-3p/ATG12 axis and Bcl-2, respectively [175, 178]. 2017;162(2):36977. $53.99 Make It a Routine. Sometimes you can find information on specific products on the OEHHA website as well. Cancer Lett. Exosomal transfer of miR-501 confers doxorubicin resistance and tumorigenesis via targeting of BLID in gastric cancer. Shen Q, Yao Q, Sun J, Feng L, Lu H, Ma Y, et al. Recently, lncRNA regulator of reprogramming (ROR) has been found to confer the resistant to ADR and VCR by up-regulating MRP1 expression in gastric cancer cells and correlated to poor patient outcomes [188]. 2014;5(22):1155263. On one hand, oncogenic miR-19a/b has been reported to enhance VCR resistance of gastric cancer cells by suppressing expression of its target gene PTEN [57]. Correlation between immune-related adverse events and prognosis in patients with gastric cancer treated with nivolumab. 2.33 Pound (Pack of 1) 4.4 out of 5 stars 630. Warning Text . 2018;15(1):599605. 2016;77(5):10617. Eur Rev Med Pharmacol Sci. For instance, significantly diminished expression of lncRNA CASC2 was observed in DDP-resistant gastric cancer tissues and cells. Mol Ther Oncolytics. Similarly, miR-193-3p and miR-147 could promote 5-FU resistance of gastric cancer cells via directly suppressing their target gene PTEN [127, 128]. Roviello G, D'Angelo A, Generali D, Pittacolo M, Ganzinelli M, Iezzi G, et al. (This is discussed below.). On the contrary, several tumor suppressor miRNAs can reverse 5-FU resistance of gastric cancer. 5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers. 2016;7(1):53849. Bao J, Xu Y, Wang Q, Zhang J, Li Z, Li D, et al. However, there are still no studies how lncRNAs and circRNAs are involved in gastric cancer resistance to targeted therapy. Zhao X, Yang L, Hu J. Down-regulation of miR-27a might inhibit proliferation and drug resistance of gastric cancer cells. Learn how to enable it, list of chemicals which can trigger a warning. Lee SD, Yu D, Lee DY, Shin HS, Jo JH, Lee YC. Oncol Rep. 2014;32(6):254956. Conversely, a number of tumor suppressor miRNAs can reverse platinum drugs resistance of gastric cancer. Google Scholar. The sensitivity of gastric cancer to trastuzumab is regulated by the miR-223/FBXW7 pathway. Fang Y, Shen H, Li H, Cao Y, Qin R, Long L, et al. In addition, oncogenic miR-135b-5p, miR-135b, miR-17-5p, miR-193a-3p, miR-4295 and miR-3174 confer DDP resistance of gastric cancer cells through silencing Krppel-like factor 4 (KLF4), mammalian ste20-like kinase 1 (MST1), p21, SRSF2, leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) and ARHGAP10, respectively [28, 92,93,94,95,96]. Zhang Y, Qu X, Li C, Fan Y, Che X, Wang X, et al. Mai D, Ding P, Tan L, Zhang J, Pan Z, Bai R, et al. Interestingly, lncRNA XLOC_006753, which is highly expressed in gastric cancer patients and MDR SGC-7901/DDP gastric cancer cells, could promote resistance to DDP through regulating the PI3K/AKT/mTOR pathway [172]. 2016;12(12):143747. 2016;22(11):134250. 5-FU is commonly applied for the treatment of gastric cancer in clinic. Wei, L., Sun, J., Zhang, N. et al. Ge X, Liu X, Lin F, Li P, Liu K, Geng R, et al. 2014;20(32):1134755. Ding J, Li D, Gong M, Wang J, Huang X, Wu T, et al. Cancer Lett. GNC Lean Shake, Total Lean: calories, nutrition analysis & more CAS Li X, Liang J, Liu YX, Wang Y, Yang XH, Luan BH, et al. MiR-192-5p reverses cisplatin resistance by targeting ERCC3 and ERCC4 in SGC7901/DDP cells. To start with, it is a product (shake) that is basically believed to be a meal replacement with a mixture of carbohydrate, cocoa, Vitamin, minerals, dry milk, creamer, the milk protein. Businesses are not required to use this exact wording (as long as it still provides a clear and reasonable warning), so it can vary somewhat between labels. Cell Physiol Biochem. Liu YT, Han XH, Xing PY, Hu XS, Hao XZ, Wang Y, et al. Cell. Peng C, Huang K, Liu G, Li Y, Yu C. MiR-876-3p regulates cisplatin resistance and stem cell-like properties of gastric cancer cells by targeting TMED3. Silence of Long Noncoding RNA NEAT1 Inhibits Malignant Biological Behaviors and Chemotherapy Resistance in Gastric Cancer. 2015;72(1):27582. Esteller M, Pandolfi PP. Advanced gastric cancer patients can notably benefit from chemotherapy including adriamycin, platinum drugs, 5-fluorouracil, vincristine, and paclitaxel as well as targeted therapy drugs. CircPAN3 mediates drug resistance in acute myeloid leukemia through the miR-153-5p/miR-183-5p-XIAP axis. The noncoding RNA revolution-trashing old rules to forge new ones. Learn more about misleading supplement labels and legality, including labels that say "formulation," "blend," or "complex.". In addition, lncRNAs PVT1 [177], HOTAIR [182] and CASC9 [183] also promoted PTX resistance of gastric cancer through modulating expression of various genes. Similarly, miR-21 has also been found to promote DDP resistance via silencing the PTEN/Akt pathway, while contrary results were observed after administration of PI3K inhibitors suppressing Akt pathway [86]. 2019;54(1):23948. Oncol Lett. Stuart-Smith K, Vanhoutte PM. GNC Total Lean | Lean Shake 25, To Go Bottles | Low-Carb Protein Shake to Improve Weight Loss & BMI | Girl Scouts Coconut Caramel | 12 Pack . Can I Avoid or Limit My Exposure to X-rays and Gamma Rays? miR-508-5p regulates multidrug resistance of gastric cancer by targeting ABCB1 and ZNRD1. GNC Lean Shakes ingredients vary depending on the flavor. In addition, elevated expression of hsa_circ_0081143 is significantly associated with lymph node metastases, advanced TNM stage and worse overall survival (OS) of gastric cancer patients [201]. Regulation of BGC-823 cell sensitivity to adriamycin via miRNA-135a-5p. Future Oncol. BMC Cancer. This tastes great SUPER cold so LOTS more Ice for me. Int J Cancer. Li LQ, Pan D, Chen Q, Zhang SW, Xie DY, Zheng XL, et al. Exogenous expression of miR-155-5p confers chemoresistance and EMT in PTX-sensitive MGC-803S cells through targeting and suppressing GATA binding protein 3 (GATA3) and tumor protein p53-inducible nuclear protein 1 (TP53INP1) [146]. Cheng C, Qin Y, Zhi Q, Wang J, Qin C. Knockdown of long non-coding RNA HOTAIR inhibits cisplatin resistance of gastric cancer cells through inhibiting the PI3K/Akt and Wnt/beta-catenin signaling pathways by up-regulating miR-34a. MiR-501 is another significantly up-regulated miRNA in SGC7901/ADR cells. 2019;110(2):66273. 2017;92:10307. . Longley DB, Harkin DP, Johnston PG. PDF Advanced Fat Metabolism Meal Plan Week 1 Moreover, circAKT3 could promote DNA damage repair and suppress apoptosis of gastric cancer cells in vitro and in vivo. Zhang XL, Shi HJ, Wang JP, Tang HS, Cui SZ. The Proposition 65 warning labels might cause some confusion for people who see them, for a few reasons: While businesses are required to put warning labels on products, theyre not required to list all of the chemicals that might cause problems, nor are they required to provide the OEHHA with any information about the products. Similarly, Bcl-2 silencing by miR-429 has also been found to sensitize gastric cancer cells to 5-FU [130]. 2018;12:57890. 2019;10(9):661. In addition, over-expression of miR-23b-3p, an autophagy-related modulator, has been found to sensitize gastric cancer cells to 5-FU by inhibiting expression of ATG12 and HMGB2 [104]. An Y, Zhang Z, Shang Y, Jiang X, Dong J, Yu P, et al. Trastuzumab, a US Food and Drug Administration (FDA) approved anti-human HER2 MoAb, combined with conventional chemotherapy has been broadly used in advanced or metastatic gastric cancer patients with HER2 overexpression/amplification. As a cell cycle non-specific anti-cancer antibiotic, ADR can inhibit the synthesis of nucleic acids through embedding into DNA and exert strong cytotoxic effects on tumor cells. Long noncoding RNA BLACAT1 modulates ABCB1 to promote oxaliplatin resistance of gastric cancer via sponging miR-361. Wei X, Gao M, Ahmed Y, Gao M, Liu W, Zhang Y, et al. Poor expression of microRNA-135b results in the inhibition of cisplatin resistance and proliferation and induces the apoptosis of gastric cancer cells through MST1-mediated MAPK signaling pathway. 2019;663:26975. See if you're eligible for a clinical trial. Biomed Pharmacother. CAS Article 2019;27(5):6238. Oncol Lett. BCAR4 increase cisplatin resistance and predicted poor survival in gastric cancer patients. Multiple miRNAs are dysregulated in gastric cancer and play a crucial role in tumorigenesis, cancer metastasis, as well as development of resistance to drugs and radiation [44,45,46,47,48]. Xu W, He L, Li Y, Tan Y, Zhang F, Xu H. Silencing of lncRNA ZFAS1 inhibits malignancies by blocking Wnt/beta-catenin signaling in gastric cancer cells. Oncotarget. Your US state privacy rights, Mol Cancer. Zhou W, Tan W, Huang X, Yu HG. Biomed Pharmacother. Via sponging endogenous miR-505 to upregulate cylindromatosis (CYLD) expression and subsequently inhibiting AKT activation, ectopic CRAL expression can weaken DDP resistance of gastric cancer cells by potentiating DDP-induced DNA damage and cell apoptosis in vitro and in preclinical models [181]. miR-200c inhibits TGF-beta-induced-EMT to restore trastuzumab sensitivity by targeting ZEB1 and ZEB2 in gastric cancer. Global Burden of Disease Cancer C, Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, et al. Californias Proposition 65, also called the Safe Drinking Water and Toxic Enforcement Act, first became law in the state in 1986. The law also has similar strict cutoff levels for birth defects and reproductive harm. LncRNA PVT1 Mediates Antiapoptosis and 5-Fluorouracil Resistance via Increasing Bcl2 Expression in Gastric Cancer.
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