View abstract. Khalife, S. and Zafarullah, M. Molecular targets of natural health products in arthritis. 2010;29(4):668-673. Arthritis Res.Ther. View abstract. Menopause 2012;19(4):426-32. 2009;18(6):553-561. View abstract. 2010;85(1):155-159. In vitro antibacterial activity of some Iranian medicinal plant extracts against Helicobacter pylori. Sastravaha G, Yotnuengnit P, Booncong P, Sangtherapitikul P. Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts. Z., Bao, L., He, R. R., and Kurihara, H. [Effect of pomegranate peel extracts on experimental prostatitis rats]. Kafkas niversitesi. 1999;13(7):616-618. Bhadbhade, S. J., Acharya, A. This might increase the effects and side effects of tolbutamide (Orinase). Gaig, P., Botey, J., Gutierrez, V., Pena, M., Eseverri, J. L., and Marin, A. J.Agric.Food Chem. Leiva, K. P., Rubio, J., Peralta, F., and Gonzales, G. F. Effect of Punica granatum (pomegranate) on sperm production in male rats treated with lead acetate. Hontecillas, R., O'Shea, M., Einerhand, A., Diguardo, M., and Bassaganya-Riera, J. Activation of PPAR gamma and alpha by punicic acid ameliorates glucose tolerance and suppresses obesity-related inflammation. Q&A: Does pomegranate juice interact with prescription drugs? Mousavinejad, G. Emam-Djomeh Z. Rezaei K. and Khodaparast M. H. H. Identification and quantification of phenolic compounds and their effects on antioxidant activity in pomegranate juices of eight Iranian cultivars. View abstract. Acta Horticulturae 2009;818:257-264. AANA Journal 2008;76(5):373-374. Australian Journal of Basic and Applied Sciences 2009;3(4):4634-4643. J Med Food 2004;7:305-8. View abstract. pii: E721. Zhang, Q., Radisavljevic, Z. M., Siroky, M. B., and Azadzoi, K. M. Dietary antioxidants improve arteriogenic erectile dysfunction. Pomegranate Juice Benefits: May Lower Blood Pressure and Improve Your Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Li, J. Li G. Zhao Y. and Yu C. Composition of pomegranate peel polyphenols and its antioxidant activities. fruits, such as kiwi and oranges. Carbamazepine (Tegretol) is broken down by the body. 2007;17(1):50-54. AANA Journal 2008;76(5):365-366. pii: E1593. Drinking pomegranate juice might decrease how quickly the body breaks down some medications. J.Food Sci. J.Agric.Food Chem. Washington, DC: National Academy Press, 2000. Possible interaction between pomegranate juice and warfarin. Schubert SY, Lansky EP, Neeman I. Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids. Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice. Food Chem.Toxicol. View abstract. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. View abstract. Seong, A. R., Yoo, J. Y., Choi, K., Lee, M. H., Lee, Y. H., Lee, J., Jun, W., Kim, S., and Yoon, H. G. Delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of NF-kappaB acetylation in fibroblast-like synoviocyte MH7A cells. 2019;11(7). One cup of brewed pomegranate tea contains: Calories: 6. 2009;9:23. Safety and antioxidant activity of pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size. Gangemi S, Mistrello G, Roncarolo D, et al. Enhancing fluorescence intensity of Ellagic acid in Borax-HCl-CTAB micelles. Long-term use of NSAIDs has also been linked to changes in kidney function. Select a condition to view a list of vitamins. Murthy KN, Reddy VK, Veigas JM, Murthy UD. View abstract. All rights reserved. J.Med.Food 2011;14(7-8):695-701. Exp.Dermatol. Integr.Cancer Ther. View abstract. Ren Fail. Does Pomegranate Interact With Any Medications? - Stellina Marfa Singh, K., Jaggi, A. S., and Singh, N. Exploring the ameliorative potential of Punica granatum in dextran sulfate sodium induced ulcerative colitis in mice. Khan, G. N., Gorin, M. A., Rosenthal, D., Pan, Q., Bao, L. W., Wu, Z. F., Newman, R. A., Pawlus, A. D., Yang, P., Lansky, E. P., and Merajver, S. D. Pomegranate fruit extract impairs invasion and motility in human breast cancer. View abstract. Appl.Environ.Microbiol. Pai, M. B., Prashant, G. M., Murlikrishna, K. S., Shivakumar, K. M., and Chandu, G. N. Antifungal efficacy of Punica granatum, Acacia nilotica, Cuminum cyminum and Foeniculum vulgare on Candida albicans: an in vitro study. Chinese Journal of Prevention and Control of Chronic Diseases 2011;19(2):185-187. Pomegranate extract inhibits Staphylococcus aureus growth and subsequent enterotoxin production. View abstract. Drug Metab Dispos 2005;33:644-8. View abstract. The reason for this is pomegranate juice isnt the only fruit with the potential to cause side effects when mixed with medicine. Whole grapefruit or grapefruit juice as well as similar foods such as Seville oranges, pomelos and tangelos interfere with medications broken down by certain enzymes in the liver. Allergy 1991;46:472-4. Subsequently, it is recommended that patients with high cholesterol should talk to their GP or doctor before they start taking ACE inhibitors or statins in order to identify any dietary hurdles that may hinder the medicines effectiveness. Ibrahium, M. I. Gasmi, J. and Sanderson, J. T. Growth Inhibitory, Antiandrogenic, and Pro-apoptotic Effects of Punicic Acid in LNCaP Human Prostate Cancer Cells. Zhongguo Zhong.Yao Za Zhi. Gil MI, Tomas-Barberan FA, Hess-Pierce B, et al. 2010;36(2):421-426. Sastravaha, G., Gassmann, G., Sangtherapitikul, P., and Grimm, W. D. Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts in supportive periodontal therapy. This information may not fit your specific health circumstances. Trombold, J. R., Reinfeld, A. S., Casler, J. R., and Coyle, E. F. The effect of pomegranate juice supplementation on strength and soreness after eccentric exercise. A. / Compostos fenlicos da polpa e sementes de rom (Punica granatum, L.): atividade antioxidante e protetora em clulas MDCK. The problem here is that it's messy and can get expensive if you buy pre-packaged and pre-seeded ones. While pomegranates lose much of their vitamin C content when juiced, they retain nearly all of their potassium, about 536 . J.Clin.Biochem.Nutr. 2003;6(2):121-128. Curr Urol Rep 2006;7:7. 2-24-2010;58(4):2180-2187. You can unsubscribe at any time. Carbonell-Barrachina . Lamb KL, Ranchordas MK, Johnson E, Denning J, Downing F, Lynn A. View abstract. 12-21-2010;703(2):99-107. View abstract. 2008;13(2):128-144. Nat.Prod.Res. J.Am.Coll.Nutr. 2009;102(1):54-59. View abstract. Parle, M. and Samal M. K. Neuroprotective effects of pomegranate juice in mice. View abstract. 9-24-2008;56(18):8434-8441. View abstract. 2011;49(4):377-382. Hepaksoy, S. Erogul D. Sen F. and Aksoy U. Antioxidant activity and total phenolic content of some Turkish pomegranate varieties. Tran, H. N., Bae, S. Y., Song, B. H., Lee, B. H., Bae, Y. S., Kim, Y. H., Lansky, E. P., and Newman, R. A. Pomegranate (Punica granatum) seed linolenic acid isomers: concentration-dependent modulation of estrogen receptor activity. 2009;46(1):106-111. 12-15-1999;68(1-3):205-208. The Herbal Alternatives for Menopause (HALT) Study: background and study design. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Nat.Rev.Urol. Mycoses 2003;46:192-6. Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. Int.J.Food Microbiol. Rosenblat, M., Volkova, N., Attias, J., Mahamid, R., and Aviram, M. Consumption of polyphenolic-rich beverages (mostly pomegranate and black currant juices) by healthy subjects for a short term increased serum antioxidant status, and the serum's ability to attenuate macrophage cholesterol accumulation. View abstract. Indian J.Biochem.Biophys. Protein: 0 grams. Nitric.Oxide. Martin, K. R. Krueger C. G. Rodriquez G. Dreher M. and Reed J. D. Development of a novel pomegranate standard and new method for the quantitative measurement of pomegranate polyphenols. Forest, C. P., Padma-Nathan, H., and Liker, H. R. Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study. Zhao, G. Li G. Dong Z. and Liu X. 2011;7(26):161-164. 2009;4(7):e6458. Park, H. M., Moon, E., Kim, A. J., Kim, M. H., Lee, S., Lee, J. 2010;24(4):1087-1091. (Tokyo) 2006;52(5):383-388. Mohan, M., Waghulde, H., and Kasture, S. Effect of pomegranate juice on Angiotensin II-induced hypertension in diabetic Wistar rats. View abstract. Sumner MD, Elliott-Eller M, Weidner G, et al. View abstract. The effects of pomegranate juice on the pharmacokinetics of simvastatin in healthy Korean subjects (PI-63). The effect remained even when consuming pomegranate juice at different amounts. Clinical Oncology Alert 2008;13(2):3-4. Jurenka, J. S. Therapeutic applications of pomegranate (Punica granatum L.): a review. View abstract. Jadeja, R. N., Thounaojam, M. C., Patel, D. K., Devkar, R. V., and Ramachandran, A. V. Pomegranate (Punica granatum L.) juice supplementation attenuates isoproterenol-induced cardiac necrosis in rats. View abstract. View abstract. Punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. Auerbach L, Rakus J, Bauer C, et al. Isr Med Assoc J 2011;13(8):474-9. Stowe, C. B. Some medications that are changed by the body include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), and S-warfarin (Coumadin). This might increase the effects and side effects of rosuvastatin (Crestor). View abstract. Syed, D. N., Malik, A., Hadi, N., Sarfaraz, S., Afaq, F., and Mukhtar, H. Photochemopreventive effect of pomegranate fruit extract on UVA-mediated activation of cellular pathways in normal human epidermal keratinocytes. Pomegranate juice can affect cholesterol medicine. Weisburg, J. H., Schuck, A. G., Silverman, M. S., Ovits-Levy, C. G., Solodokin, L. J., Zuckerbraun, H. L., and Babich, H. Pomegranate extract, a prooxidant with antiproliferative and proapoptotic activities preferentially towards carcinoma cells. Herbal supplements can interact with medicines used to treat heart and blood vessel problems, such as high blood pressure and heart failure. Rababah, T. M., Banat, F., Rababah, A., Ereifej, K., and Yang, W. Optimization of extraction conditions of total phenolics, antioxidant activities, and anthocyanin of oregano, thyme, terebinth, and pomegranate. 2011;3(7):742-754. Pomegranate might decrease how quickly the body breaks down some medications. Gonzalez-Ortiz M, Martinez-Abundis E, Espinel-Bermudez MC, Perez-Rubio KG. 2009;34(10):1290-1294. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. J Agric Food Chem 2009;57(16):7395-400. View abstract. View abstract. To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact . View abstract. View abstract. The effect of pomegranate (Punica granatum) supplementation on metabolic status in patients with type 2 diabetes: A systematic review and meta-analysis. J Ethnopharmacol 2005;96:335-9. 9-24-2008;56(18):8704-8713. Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases. View abstract. J Ethnopharmacol 2005;96:171-6. One year of pomegranate juice intake decreases oxidative stress, inflammation, and incidence of infections in hemodialysis patients: a randomized placebo-controlled trial. A systematic review and meta-analysis of randomized controlled clinical trials. View abstract. Cardiovasc.Toxicol. Fuhrman, B., Volkova, N., and Aviram, M. Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages. 2008;22(12):2723-2731. Taking pomegranate along with some medications that are changed by the body might increase the effects and side effects of your medication. Potential antiparasitic activity of pomegranate extracts against shistosomules and mature worms of Schistosoma mansoni: in vitro and in vivo study. Studies on the toxicity of Punica granatum L. (Punicaceae) whole fruit extracts. Higiene Alimentar 2009;23(168/169):54-56. Cerda, B., Espin, J. C., Parra, S., Martinez, P., and Tomas-Barberan, F. A. Muscle strength. Phytother.Res. J.Agric.Food Chem. But drinking pomegranate juice doesn't seem to prevent narrowing of blood vessels in the heart (stenosis). View abstract. Early research shows that rinsing with pomegranate extract mouthwash for one minute once or twice daily reduces dental plaque. That study, which also includes pomegranates and celery on the list of foods with furanocoumarin, concluded that moderate amounts of grapefruit won't interfere significantly with statins. 2008;32(2):475-480. Seeram, N. P., Henning, S. M., Zhang, Y., Suchard, M., Li, Z., and Heber, D. Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. nuts, for example, pistachios and walnuts. Hanley MJ, Masse G, Harmatz JS, et al. Pomegranate can lower blood pressure. View abstract. Asian Journal of Chemistry 2011;23(7):3131-3234. Pantuck AJ, Pettaway CA, Dreicer R, et al. Some medications are changed and broken down by the body. Maturitas 10-16-2005;52(2):134-146. Early research shows that taking pomegranate extract can improve muscle strength recovery after exercise. Some studies indicated that pomegranate juice reduces blood pressure in hypertensive and normotensive populations. 2019;11(4). de Nigris, F., Balestrieri, M. L., Williams-Ignarro, S., D'Armiento, F. P., Fiorito, C., Ignarro, L. J., and Napoli, C. The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats. 2021;81(1):41-49. Complement Ther Clin Pract 2022;46:101544. Spectrochim.Acta A Mol.Biomol.Spectrosc. View abstract. Int.J.Food Microbiol. 2006;15(2):93-102. Ann N Y Acad Sci 2005;1056:311-27. Problems arise because natural chemicals or nutrients in foods or drinks can interfere with a medication, lessening its effectiveness or potentially having a stronger affect. A., Salem, M. F., El-Tras, W. F., and Brimer, L. Exploration of Islamic medicine plant extracts as powerful antifungals for the prevention of mycotoxigenic Aspergilli growth in organic silage. O'May, C. and Tufenkji, N. The swarming motility of Pseudomonas aeruginosa is blocked by cranberry proanthocyanidins and other tannin-containing materials. View abstract. Accessed June 1, 2016. Zhang, J., Zhan, B., Yao, X., Gao, Y., and Shong, J. 1992;2(4):216-218. However, certain foods and drinks can make warfarin work not as well at preventing blood clots. Pomegranate: Health Benefits, Side Effects, Uses, Dose - RxList Rettig, M. B., Heber, D., An, J., Seeram, N. P., Rao, J. Y., Liu, H., Klatte, T., Belldegrun, A., Moro, A., Henning, S. M., Mo, D., Aronson, W. J., and Pantuck, A. Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism. A lung disease that makes it harder to breathe (chronic obstructive pulmonary disease or COPD). Mattiello, T., Trifiro, E., Jotti, G. S., and Pulcinelli, F. M. Effects of pomegranate juice and extract polyphenols on platelet function. Pomegranate juice can interact with medications to cause side effects Romier-Crouzet, B., Van De Walle, J., During, A., Joly, A., Rousseau, C., Henry, O., Larondelle, Y., and Schneider, Y. J. Inhibition of inflammatory mediators by polyphenolic plant extracts in human intestinal Caco-2 cells. View abstract. Screening of certain medicinal plants from India for their anti-quorum sensing activity. Study on wound healing activity of Punica granatum peel. 2015;18(3):242-8. READ MORE:Gloria Hunniford health: The 'horror' food that caused pre-diabetes. 2009;47(2):125-132. Arthritis Res.Ther. We Recommend Nutrition How Bad Is It Really to Try a Teatox? This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. The British Heart Foundation says: If youre taking simvastatin or atorvastatin, avoid grapefruit and grapefruit juice as they can increase your risk of side effects. Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. View abstract. Eur J Drug Metab Pharmacokinet 2016;41(4):339-44. View abstract. Athletic performance. This might increase the effects and side effects of warfarin (Coumadin). / Hicaz nar srasnn organik asit seker ve fenol bilesikleri icerigI ve antioksidan kapasitesi. Iranian Journal of Endocrinology and Metabolism 2008;9:399-405, 470. If you're drinking pomegranate juice and taking statin drugs, it's important to tell your doctor. View abstract. Yes, lemon juice can interact with blood pressure medication. Screening of traditional Chinese medicinal plants for quorum-sensing inhibitors activity. Guo, G., Wang, H. X., and Ng, T. B. Pomegranin, an antifungal peptide from pomegranate peels. 2010;20(1):73-77. 2010;24(2):182-185. Various parts of the tree and fruit are used to make medicine. View abstract. Drinking pomegranate juice might decrease how fast the body breaks down warfarin (Coumadin). Kyralan, M. Glkc M. and Tokgz H. Oil and Conjugated Linolenic Acid Contents of Seeds from Important Pomegranate Cultivars ( Punica granatum L.) Grown in Turkey. View abstract. J Ethnopharmacol. 2008;30(3):183-193. View abstract. Integr.Biol.(Camb.) This, in turn, will reduce heart disease and other cardiovascular diseases. View abstract. Orak, H. H. Demirci A. S. and Gms T. Antibacterial and antifungal activity of pomegranate (Punica granatum L. Fitoterapia 2001;72(2):171-173. Sahebkar A, Ferri C, Giorgini P, Bo S, Nachtigal P, Grassi D. Effects of pomegranate juice on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J Chromatogr 1988;438:438-42. Adverse reaction to pomegranate ingestion. Enrique E, Utz M, De Mateo JA, et al. 2010;104(3):402-406. See today's front and back pages, download the newspaper, order back issues and use the historic Daily Express newspaper archive. Early research in trained men shows that drinking pomegranate juice twice daily for 15 days reduces muscle soreness after, A grouping of symptoms that increase the risk of diabetes, heart disease, and stroke (. Erectile dysfunction (ED). Abedini M, Ghasemi-Tehrani H, Tarrahi MJ, Amani R. The effect of concentrated pomegranate juice consumption on risk factors of cardiovascular diseases in women with polycystic ovary syndrome: A randomized controlled trial. View abstract. Panichayupakarananta, P., Issuriya, A., Sirikatitham, A., and Wang, W. Antioxidant assay-guided purification and LC determination of ellagic acid in pomegranate peel. Pharmacotherapy 2009;29:1002-6. View abstract. Paller CJ, Ye X, Wozniak PJ, et al. de Nigris, F., Williams-Ignarro, S., Sica, V., Lerman, L. O., D'Armiento, F. P., Byrns, R. E., Casamassimi, A., Carpentiero, D., Schiano, C., Sumi, D., Fiorito, C., Ignarro, L. J., and Napoli, C. Effects of a pomegranate fruit extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis. View abstract. View abstract. Ren Fail. Nicole Cutler L.Ac. View abstract. View abstract. Ann Allergy Asthma Immunol 2006;96(1):122-3. 6-9-2010;58(11):6804-6808. While a lot of attention is paid to how different medications interact with each other, less attention is put to how medications interact with easy to buy and consume liquids. Dementia: Smell that? Fish.Shellfish.Immunol. Journal of Medicinal Plants Research 2011;5(6):1004-1011. Pomegranate juice appeared to decrease SBP and DBP in a dose-dependent manner, but the benefit was lost after 2 months of pomegranate juice intake. View abstract. Int J Obes 2007;31:1023-9. Pomegranate ( Punica granatum ), a polyphenol-rich fruit, has been suggested to reduce cardiovascular risk due to its antioxidant properties. Br.J.Nutr. Pomegranate juice and pomegranate extract do not impair oral clearance of flurbiprofen in human volunteers: divergence from in vitro results. Some medications are changed and broken down by the body. It's important to pay attention to what you eat while taking warfarin. An aqueous pomegranate peel extract inhibits neutrophil myeloperoxidase in vitro and attenuates lung inflammation in mice. Crum EM, Barnes MJ, Stannard SR. Multiday pomegranate extract supplementation decreases oxygen uptake during submaximal cycling exercise, but cosupplementation with N-acetylcysteine negates the effect. Biofactors 2007;31(1):17-24. Int J Cancer 1-20-2005;113(3):423-433. 2010;9:208. 2010;7(1):21-30. Harikrishnan, R., Heo, J., Balasundaram, C., Kim, M. C., Kim, J. S., Han, Y. J., and Heo, M. S. Effect of Punica granatum solvent extracts on immune system and disease resistance in Paralichthys olivaceus against lymphocystis disease virus (LDV). View abstract. 2011;16(3):245-253. A., Furletti, V. F., Foglio, M. A., and Goncalves, R. B. Antimicrobial potential of some plant extracts against Candida species. Complement Ther Med. 2010;19(8):e182-e190. 2010;21(8):717-725. Complement Ther Med. Effects of pomegranate juice on blood pressure: A systematic - PubMed Rattanachaikunsopon, P. and Phumkhachorn, P. Use of asiatic pennywort Centella asiatica aqueous extract as a bath treatment to control columnaris in Nile tilapia. Pharm.Biol. View abstract. Wolfe, K. L., Kang, X., He, X., Dong, M., Zhang, Q., and Liu, R. H. Cellular antioxidant activity of common fruits. Vroegrijk, I. O., van Diepen, J. View abstract. Phytomedicine 2009;16:1127-36. Clin Microbiol Infect 2005;11:510-2. 2011;25(11):1059-1066. View abstract. Research suggests that pomegranate juice may help reduce high blood pressure, which is one of the major risk factors for heart disease, per a January 2017 review in Pharmacological Research. A randomized, double-blind, placebo-controlled study of the effects of pomegranate extract on rising PSA levels in men following primary therapy for prostate cancer. Pirbalouti, A. G., Azizi, S., Koohpayeh, A., and Hamedi, B. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Allergy to lipid transfer proteins: cross-reactivity among pomegranate, hazelnut, and peanut. Pakistan Journal of Nutrition 2009;8(8):1251-1257. We examined the effects of tart cherry juice on lipid profiles, BP, glucose, insulin, and homeostatic model assessment-insulin resistance (HOMA-IR) in older adults. Food Chem.Toxicol. A. and Prez-Lpez A. J. Navarro, P. Nicolas T. S. Gabaldon J.
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